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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
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Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Published on: August 2, 2018

Prostate cancer proteomics.

John R Masters1

  • 1Prostate Cancer Research Centre, UCL, London, United Kingdom. j.masters@ucl.ac.uk

Omics : a Journal of Integrative Biology
|February 16, 2011
PubMed
Summary
This summary is machine-generated.

Proteomics offers hope for prostate cancer biomarker discovery. However, current research has yielded limited clinically valuable or reproducible results for patient management.

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Last Updated: Jun 4, 2026

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Area of Science:

  • Biochemistry
  • Oncology
  • Medical Diagnostics

Background:

  • Prostate cancer management requires reliable biomarkers for screening, diagnosis, and treatment guidance.
  • Proteomics presents a potential avenue for discovering these crucial biomarkers.
  • Existing diagnostic and prognostic tools for prostate cancer have limitations.

Purpose of the Study:

  • To review the potential of proteomics in prostate cancer biomarker discovery.
  • To assess the current state of proteomic research in prostate cancer.
  • To identify challenges and limitations in the field.

Main Methods:

  • Literature review of proteomic studies related to prostate cancer.
  • Analysis of various protein sources (urine, serum, tissue) and proteomic platforms.
  • Evaluation of the clinical relevance and reproducibility of published findings.

Main Results:

  • Proteomics has shown promise for identifying prostate cancer biomarkers.
  • Numerous potential protein sources and analytical platforms exist.
  • Most published proteomic research lacks clinical value and reproducibility.

Conclusions:

  • Despite its potential, proteomics has not yet delivered clinically useful biomarkers for prostate cancer management.
  • Further research is needed to overcome reproducibility and clinical relevance challenges.
  • The clinical utility of current proteomic findings in prostate cancer is minimal.