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Clinical research databases--a historical review.

¹Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94611.

Journal of Medical Systems

|December 1, 1990

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Clinical research databases have evolved significantly over 30 years. This review covers their development, data processing challenges, and types of registers.

Area of Science:

Clinical research informatics
Health data management

Background:

The critical role of computer-stored databases in modern clinical research.
The need to understand the historical trajectory of these data management systems.

Observation:

A comprehensive review of the evolution of clinical research databases over the last three decades.
Identification of unique challenges in computer processing of clinical research data.
Categorization and description of diverse clinical research registers and databases.

Findings:

Databases have become indispensable tools in clinical research over the past 30 years.
Specific technical and logistical problems arise during the computer processing of clinical research data.
A variety of specialized registers and databases exist to support different facets of clinical research.

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Implications:

Informed decisions for future database development and implementation in clinical research.
Enhanced understanding of data processing challenges can lead to improved data quality and integrity.
Knowledge of existing database types facilitates selection of appropriate tools for specific research needs.