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Evolutionary bioscience as regulatory systems biology.

Eric H Davidson¹

¹Division of Biology, California Institute of Technology, Pasadena, 91125, USA. Davidson@caltech.edu

Developmental Biology

|February 16, 2011

Summary

This summary is machine-generated.

Evolution of animal body plans results from changes in gene regulatory networks. These networks

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Area of Science:

Evolutionary developmental biology
Genomics
Systems biology

Background:

Multiple theories explain animal body plan evolution.
Modern genomics and developmental regulation offer new insights.

Purpose of the Study:

To explore evolutionary mechanisms of body plans.
To consider developmental processes at a systems level.

Main Methods:

Analysis of gene regulatory networks (GRNs).
Examination of developmental gene regulation.
Systems-level causal explanation.

Main Results:

Body plan evolution involves altering GRN structure.
GRNs produce Boolean regulatory state specifications.
Upstream GRN outputs are robust to continuous variation.

Conclusions:

Developmental gene regulatory networks are key to body plan evolution.
Network architecture influences evolutionary potential.
Robustness of core developmental processes constrains adaptive variation.