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Central pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) decrease

Frédéric Lancien¹, Nagi Mimassi, J Michael Conlon

¹Université Européenne de Bretagne, INSERM U650, Laboratoire de Traitement de l'Information Médicale, IFR 148 ScInBioS, Faculté de Médecine et des Sciences de la Santé, 22 Avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, CHU de Brest, France.

General and Comparative Endocrinology

|February 16, 2011

Summary

This summary is machine-generated.

Pituitary adenylate cyclase-activating peptides (PACAP) and vasoactive intestinal peptides (VIP) reduce cardiac baroreflex sensitivity (BRS) in trout. These peptides may play a role in the central nervous system

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Area of Science:

Neuroendocrinology
Cardiovascular Physiology
Comparative Physiology

Background:

Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) are known to influence cardiovascular functions.
The role of PACAP and VIP in regulating the baroreflex response, crucial for blood pressure homeostasis, remains largely unexplored.
Understanding these roles is vital for comprehending cardiovascular control mechanisms across vertebrates.

Purpose of the Study:

To investigate the involvement of PACAP and VIP in the central regulation of cardiac baroreflex sensitivity (BRS).
To determine the effects of intracerebroventricular (i.c.v.) and intra-arterial administration of PACAP and VIP on BRS in rainbow trout.
To elucidate the potential contribution of these peptides to blood pressure regulation.

Main Methods:

Utilized unanesthetized rainbow trout (Oncorhynchus mykiss) as the experimental model.
Employed cross-spectral analysis with fast Fourier transform to assess BRS by analyzing spontaneous fluctuations in systolic arterial blood pressure and R-R intervals.
Calculated coherence, phase, and gain of the transfer function to estimate BRS under different conditions.

Main Results:

Intracerebroventricular (i.c.v.) administration of trout PACAP-27 and trout VIP (25-100 pmol) dose-dependently reduced cardiac BRS.
A threshold dose of 50 pmol for both PACAP and VIP was found to significantly attenuate BRS when administered i.c.v.
Intra-arterial injection of VIP (100 pmol) also significantly attenuated BRS, suggesting both central and peripheral influences.

Conclusions:

Endogenous PACAP and VIP are implicated in the central control of cardiac baroreflex functions in trout.
These findings suggest a significant role for PACAP and VIP in modulating blood pressure homeostasis through baroreflex pathways.
Further research is warranted to fully understand the neuroendocrine mechanisms underlying PACAP and VIP actions on the cardiovascular system.