Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 4, 2026

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
05:18

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

Published on: January 16, 2026

Transapical miniaturized ventricular assist device: design and initial testing.

Mark S Slaughter1, Guruprasad A Giridharan, Dan Tamez

  • 1Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202, USA. mark.slaughter@louisville.edu

The Journal of Thoracic and Cardiovascular Surgery
|February 16, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What Makes a Great Manuscript?

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Transcatheter or Surgical Aortic-Valve Replacement at 7 Years.

The New England journal of medicine·2026
Same author

Integrative Clinical-Molecular Modeling Identifies <i>LRRN4CL</i> as a Determinant of Structural and Functional Myocardial Improvement.

bioRxiv : the preprint server for biology·2026
Same author

Retrograde perfusion of the dorsalis pedis artery versus traditional distal perfusion catheter use in venoarterial extracorporeal membrane oxygenation.

JTCVS open·2026
Same author

Modifying a traditional femoral venoarterial extracorporeal membrane oxygenation cannulation strategy and circuit to improve distal limb hemodynamics.

JTCVS open·2026
Same author

Local amiodarone delivery via an extracellular collagen matrix patch to reduce new-onset postoperative atrial fibrillation.

JTCVS open·2026
Same journal

Oncological Outcomes of Left Upper Tri-segmentectomy vs. Lobectomy for Clinical Stage I NSCLC with Occult Lymph Node Metastasis: A Target Trial Emulation with Targeted Minimum Loss-Based Estimation and Propensity Score Matching.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Pushing the Age Limit: Mitral Valve Surgery Is Safe and Effective in Octogenarians.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Bridging Pediatric and Young Adult Cancer Survivorship: Defining the Thoracic Surgeon's Role Across the Continuum.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Beyond compensatory expansion: Extending 3-dimensional computed tomography volumetry toward lung-preserving local therapy.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

A CALL FOR STANDARDIZATION OF HYBRID ARCH FROZEN ELEPHANT TRUNK OUTCOMES REPORTING.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Pediatric Mitral Valve Surgery: Current Practice from the European Congenital Heart Surgeons Association Congenital Database Analysis.

The Journal of thoracic and cardiovascular surgery·2026
See all related articles

A new miniaturized left ventricular assist device (LVAD) was successfully implanted via a minimally invasive transapical approach in a bovine model. This novel LVAD shows promise for earlier-stage heart failure treatment with no device-related complications.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Medical Devices

Background:

  • Left ventricular assist devices (LVADs) are crucial for advanced heart failure patients.
  • Current LVADs often require complex surgical procedures.
  • A need exists for less invasive LVADs for earlier intervention.

Purpose of the Study:

  • To evaluate the feasibility and safety of a novel miniaturized ventricular assist device.
  • To assess the transapical implantation technique for LVADs.
  • To determine the hemodynamic efficacy and biocompatibility of the device.

Main Methods:

  • A miniaturized transapical ventricular assist device was implanted in 10 bovine models.
  • Implantation was performed via left thoracotomy without cardiopulmonary bypass.

More Related Videos

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

Related Experiment Videos

Last Updated: Jun 4, 2026

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
05:18

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

Published on: January 16, 2026

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

  • Hemodynamic, echocardiographic, and hematologic parameters were assessed.

    • Main Results:

    • Successful implantation of the LVAD through the left ventricular apex in all animals.
    • The device maintained normal end-organ perfusion with minimal hemolysis.
    • No pump failures, device-related complications, or thromboembolism were observed.

    Conclusions:

    • A novel intraventricular assist device is feasible via transapical apex implantation.
    • This approach avoids sternotomy, cardiopulmonary bypass, and graft anastomosis.
    • The transapical technique offers a less invasive option for LVAD therapy.