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Updated: Jun 4, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
Published on: January 12, 2024
Diabetes mellitus and early age-related macular degeneration
Jae Kyung Choi1, Youl Lee Lym, Jun Woong Moon
1Department of Family Medicine, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, Korea.
Objective:
To examine the association of diabetes mellitus and early age-related macular degeneration (AMD) in Korean adults 50 years and older.
Methods:
This study included 3008 participants aged 50 to 87 years. Early AMD was assessed from retinal photographs based on a modified Wisconsin AMD grading system. Diabetes mellitus was defined as a fasting glucose level of 126 mg/dL or greater or the use of antidiabetic medications. Logistic regression was used to examine the association between diabetes mellitus and early AMD.
Results:
There were 88 subjects with early AMD and 315 subjects with diabetes mellitus. After adjusting for age, sex, current smoking, obesity, and hypertension, significant association was found between diabetes mellitus and early AMD. Subjects with diabetes mellitus were more likely to have early AMD (odds ratio, 1.87; 95% confidence interval, 1.07-3.28) than were those without diabetes mellitus.
Conclusion:
There is a relationship between diabetes mellitus and early AMD in Korean adults 50 years and older. The underlying biological processes remain to be determined.
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