Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Knee Joint01:23

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatric Pes Planovalgus and Femoral Antetorsion: Understanding a Biomechanical Unit: A Narrative Review of the Proximal-to-Distal Kinetic Chain in Childhood Flatfoot.

Children (Basel, Switzerland)·2026
Same author

Human medical documentation significantly outperforms ChatGPT-4o in critical clinical dimensions: A blinded comparative assessment in paediatric orthopaedics.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Risk of Total Ankle Arthroplasty or Ankle Fusion Following Distal Tibial Fractures: A Systematic Review and Meta-Analysis.

Journal of functional morphology and kinesiology·2026
Same author

SPECT/CT peak tracer uptake is a strong predictor of aseptic loosening in painful total knee arthroplasty.

European journal of nuclear medicine and molecular imaging·2026
Same author

Complex Surgical Management of Permanent Patellar Dislocation in an Adolescent: An Eight-Year Follow-Up Case Report.

Children (Basel, Switzerland)·2025
Same author

Mid-to-Long-term Clinical Outcomes of Ankle Arthroscopy on the Treatment of Chronic Ankle Conditions: Systematic Review and Meta-analysis.

Foot & ankle specialist·2025

Related Experiment Video

Updated: Jun 4, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Pain in osteochondral lesions.

Martin Wiewiorski1, Geert Pagenstert, Helmut Rasch

  • 1University Hospital Basel, Spitalsstrasse 21, Basel 4031, Switzerland. mwiewiorski@uhbs.ch

Foot & Ankle Specialist
|February 16, 2011
PubMed
Summary

Single-photon emission computed tomography-computed tomography (SPECT-CT) imaging reveals a strong link between abnormal bone activity in osteochondral lesions (OCLs) and ankle pain. This finding highlights the importance of addressing affected bone tissue in OCL treatment strategies.

More Related Videos

Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement
04:22

Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jun 4, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement
04:22

Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement

Published on: June 13, 2025

Area of Science:

  • Orthopedics
  • Radiology
  • Pain Management

Background:

  • Osteochondral lesions (OCLs) of the ankle joint commonly cause significant pain.
  • Conventional radiographic imaging often fails to identify the precise pain source within OCLs.
  • SPECT-CT offers advanced imaging for accurate localization and characterization of OCLs.

Purpose of the Study:

  • To investigate the correlation between SPECT-CT findings and pain levels in patients with ankle OCLs.
  • To determine if pathological bone uptake on SPECT-CT is associated with patient-reported pain.
  • To assess the utility of SPECT-CT in guiding OCL treatment decisions.

Main Methods:

  • 15 patients with unilateral ankle OCLs were evaluated.
  • Pain was quantified using the Visual Analogue Scale (VAS).
  • SPECT-CT imaging was performed, followed by CT-guided intra-articular injection with local anesthetic and contrast, with post-injection VAS recorded.

Main Results:

  • All 15 patients experienced pain relief after the anesthetic injection.
  • A highly significant correlation was observed between pathological uptake on SPECT-CT and reported pain.
  • SPECT-CT effectively localized the OCL and correlated with pain intensity.

Conclusions:

  • Pathologically remodeled bone tissue within OCLs is a significant contributor to ankle pain.
  • SPECT-CT imaging is a valuable tool for identifying the pain generators in ankle OCLs.
  • Treatment strategies for OCLs should consider the involvement of specific bone tissue identified by SPECT-CT.