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Updated: Jun 4, 2026

Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids from Fermentation Broth Using Hollow-Fiber Membranes

Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids from Fermentation Broth Using Hollow-Fiber Membranes

Published on: August 9, 2024

New apparatus for liquid-liquid extraction, "emulsion flow" extractor.

Nobuyuki Yanase¹, Hirochika Naganawa, Tetsushi Nagano

¹Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319-1195, Japan. yanase.nobuyuki@jaea.go.jp

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry

|February 16, 2011

Summary

A novel emulsion flow extractor offers efficient liquid-liquid extraction without mechanical mixing. This low-cost device demonstrates excellent mixing and phase separation, outperforming traditional methods.

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Area of Science:

Chemical Engineering
Separation Science
Radiochemistry

Background:

Liquid-liquid extraction is crucial for separating and purifying chemical species.
Traditional methods often require mechanical agitation, increasing energy consumption and complexity.
Developing efficient, low-cost extraction technologies is an ongoing challenge.

Purpose of the Study:

To develop and evaluate a novel, simple, and low-cost liquid-liquid extraction apparatus.
To assess the performance of the "emulsion flow" extractor for extracting Ytterbium(III) and Uranium(VI).
To compare the efficiency and phase-separating ability of the emulsion flow extractor with conventional methods.

Main Methods:

Development of an "emulsion flow" extractor utilizing sprayed micrometer-sized droplets.
Generation of an emulsified fluid flow within a column.
Destabilization of the emulsion flow via a sudden decrease in velocity in an expanded cross-section.
Evaluation of extraction efficiency for Yb(III) and U(VI) from nitric acid solutions using bis(2-ethylhexyl) phosphoric acid (D2EHPA) in isooctane.

Main Results:

The emulsion flow extractor achieved efficient liquid-liquid extraction without continuous mechanical forces.
Mixing efficiency was found to be comparable to that of a mixer-settler.
The apparatus demonstrated a significant advantage in phase-separating ability.

Conclusions:

The developed emulsion flow extractor is a simple, low-cost, and efficient alternative for liquid-liquid extraction.
Its comparable mixing and superior phase separation capabilities make it a promising technology.
This method offers a new approach for continuous and efficient separation processes.