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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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Related Experiment Video

Updated: Jun 4, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
08:35

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

A simple solution for wound coverage by skin stretching.

Ravichand Ismavel1, Sumant Samuel, P R J V C Boopalan

  • 1Department of Orthopaedics Unit III, Christian Medical College, Vellore, Tamilnadu, India.

Journal of Orthopaedic Trauma
|February 16, 2011
PubMed
Summary
This summary is machine-generated.

Skin stretching, utilizing its viscoelastic properties, offers a simple technique for wound closure. This method effectively covers wounds, even those exposing bone, with good results and few complications.

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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

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Last Updated: Jun 4, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
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Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
08:50

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Surgical Innovation

Background:

  • Skin exhibits viscoelastic properties, including creep and stress relaxation, enabling temporary stretching.
  • Traditional wound closure methods are sometimes insufficient for complex injuries.

Observation:

  • A novel technique,
  • wound coverage by skin stretching
  • utilizes skin's viscoelasticity.
  • Kirschner wires and improvised traction bands apply dynamic traction to wound edges.

Findings:

  • The skin stretching technique successfully closed 10 challenging wounds in eight patients.
  • This method is simple, economical, and effective for rapid functional wound closure.
  • It is particularly useful for wounds exposing bone or other deep structures.

Implications:

  • This technique offers a valuable, low-resource solution for complex wound management.
  • It requires no specialized training or equipment, making it widely accessible.
  • Good outcomes and minimal complications suggest broad applicability in surgical settings.