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Hormone, inorganic phosphate concentrations and enzyme activity in hemodialyzed and kidney-transplanted children
A Szabo1, L Sarkozi, I Jaszovszki
1First Department of Pediatrics, Semmelweis University Medical School, Budapest, Hungary.
Insights
Kidney disease impacts hormone levels in children. Hemodialysis altered many hormones, but kidney transplants helped most normalize, except for elevated angiotensin-converting enzyme and alkaline phosphatase.
Area of Science:
- Pediatric Nephrology
- Biochemistry
- Endocrinology
Background:
- Children with kidney disease often exhibit hormonal imbalances.
- Hemodialysis and kidney transplantation are key interventions for pediatric kidney failure.
Purpose of the Study:
- To investigate serum hormone concentrations, enzyme activities, and inorganic phosphate complexes in pediatric patients undergoing hemodialysis and after kidney transplantation.
- To compare these biochemical markers with healthy controls.
Main Methods:
- Analysis of serum hormone levels, enzyme activities (angiotensin-converting enzyme, alkaline phosphatase, amylase, lipase, plasma renin), and inorganic phosphate complexes (CaHPO4) in three groups: hemodialyzed children, kidney-transplanted children, and healthy controls.
Main Results:
- Hemodialyzed children showed significant differences in 10 of 14 hormone levels compared to controls.
- Post-transplantation, most hormone levels normalized, but angiotensin-converting enzyme and alkaline phosphatase remained elevated.
- Dialysis minimally affected the CaHPO4 complex; plasma renin activity decreased, while amylase and lipase activities increased in hemodialyzed patients.
Conclusions:
- Kidney transplantation effectively normalizes many hormone levels affected by hemodialysis in children.
- Persistent elevation of certain enzymes post-transplantation warrants further investigation.
- Specific enzyme and hormone profiles differ significantly between hemodialysis, post-transplantation, and healthy states in pediatric kidney disease.
Abstract:
Several serum hormone concentrations, enzyme activities, and inorganic phosphate complexes were investigated in 13 hemodialyzed children, 7 kidney-transplanted children, and in 15 healthy controls. Prior to kidney transplantation 10 of the 14 tested hormone levels of hemodialyzed children differed significantly from those of healthy controls; however, after kidney transplantation most of them normalized, only the angiotensin-converting enzyme and alkaline phosphatase activities were significantly elevated in comparison with the control group. Among the different inorganic phosphate complexes, dialysis had the least effect on the CaHPO4 complex. In the hemodialyzed group the plasma renin activities were decreased and the amylase and lipase activities were increased.