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Haemodynamic aspects and serotonin.

H Dabiré1, C Cherqui, M Safar

  • 1INSERM U 228, Faculté de Médecine Broussais Hôtel-Dieu, Paris, France.

Clinical Physiology and Biochemistry
|January 1, 1990
PubMed
Summary
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Serotonin (5-HT) has complex effects on blood pressure, causing initial drops, then rises, and finally sustained decreases. These changes involve alterations in cardiac output and total peripheral resistance, mediated by various serotonin receptors.

Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Neuroscience

Background:

  • Serotonin (5-HT) is a neurotransmitter with known cardiovascular effects.
  • The precise mechanisms and receptor subtypes involved in 5-HT's impact on blood pressure and regional hemodynamics require further elucidation.

Purpose of the Study:

  • To investigate the biphasic and triphasic effects of serotonin on blood pressure.
  • To explore the roles of different serotonin receptor subtypes in mediating these hemodynamic changes.
  • To understand the differential effects of serotonin on various vascular beds.

Main Methods:

  • Administration of serotonin (5-HT) to assess its impact on blood pressure.
  • Analysis of changes in cardiac output and total peripheral resistance.

Related Experiment Videos

  • Investigation of receptor-mediated effects, focusing on 5-HT1, 5-HT2, and 5-HT3 receptor subtypes.

    • Main Results:

    • Serotonin induced a transient decrease, followed by an increase, and a prolonged decrease in blood pressure.
    • The initial decrease was linked to bradycardia and reduced cardiac output; the subsequent increase involved elevated cardiac output and peripheral resistance; the final decrease was attributed to reduced peripheral resistance.
    • Serotonin elicited both vasoconstriction (primarily via 5-HT2 receptors in large arteries) and vasodilation (mainly via 5-HT1-like receptors), with potential involvement of other subtypes.

    Conclusions:

    • Serotonin exerts complex, dose- and receptor-dependent effects on blood pressure and hemodynamics.
    • Different serotonin receptor subtypes (5-HT1, 5-HT2, 5-HT3) play distinct roles in mediating vasoconstriction and vasodilation.
    • The vascular response to serotonin varies significantly across different vascular beds and species.