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IgLONs form heterodimeric complexes on forebrain neurons

Christine J McNamee1, Sahar Youssef, Diana Moss

  • 1Department of Human Anatomy and Cell Biology, Liverpool University, UK.

Cell Biochemistry and Function
|February 16, 2011
PubMed

IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth and synaptogenesis and may act as tumour suppressor genes. Recently we have proposed that two members of the IgLON family act as a heterodimeric complex termed DIgLON. Neurons isolated from chick forebrain co-express all six combinations of IgLONs and the intensity of fluorescence for each pair of IgLONs was highly correlated. Antibody-patching experiments on forebrain neurons show complex formation for IgLON pairs but not between unrelated GPI-anchored glycoproteins. Thus IgLONs are the first GPI-anchored family of glycoproteins shown to form heterodimeric complexes in the plane of the membrane.

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