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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

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Related Experiment Video

Updated: Jun 4, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

Prognosis: a variable parameter: dynamic prognostic modeling in head and neck squamous cell carcinoma.

Marc P van der Schroeff1, Ewout W Steyerberg, Marjan H Wieringa

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Erasmus Medical Center, Rotterdam, The Netherlands. m.vanderschroeff@erasmusmc.nl

Head & Neck
|February 16, 2011
PubMed
Summary

Cancer patient prognosis is not static. New models show how survival time, recurrences, and metastasis dynamically change head and neck squamous cell carcinoma (HNSCC) patient outlooks over time.

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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Published on: January 5, 2017

Related Experiment Videos

Last Updated: Jun 4, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

Area of Science:

  • Oncology
  • Medical Statistics
  • Cancer Research

Background:

  • Traditional cancer prognosis often relies on initial diagnosis, treating outcomes as fixed.
  • Patient outlooks evolve, especially after surviving initial critical periods or if cancer recurs or metastasizes.

Purpose of the Study:

  • To develop dynamic prognostic models for head and neck squamous cell carcinoma (HNSCC).
  • To assess how survival time, recurrences, and metastasis impact prognosis during follow-up.

Main Methods:

  • Analysis of 2927 patients with primary head and neck squamous cell carcinoma (HNSCC).
  • Development of prognostic models at initial treatment and various follow-up intervals.

Main Results:

  • Models demonstrated the influence of survival duration, recurrences, and distant metastasis on patient outcomes.
  • Model performance, measured by C-statistics, ranged from 0.76 to 0.69.

Conclusions:

  • Cancer prognosis is dynamic, influenced by time and life events like recurrence or metastasis.
  • These models offer improved understanding of prognostic changes and can aid patient counseling.