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Updated: Jun 4, 2026

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
08:55

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Published on: May 18, 2018

[The intestinal infarct. Personal casistics and management of the patients]

Antonio Biondi1, Alessandro Tropea, Giuliana Monaco

  • 1Università degli Studi di Catania.

Annali Italiani Di Chirurgia
|February 17, 2011
PubMed

Insights

Acute mesenteric ischemia, often caused by superior mesenteric artery emboli, requires prompt surgical intervention. This study evaluated treatment outcomes for intestinal infarction, highlighting the need for timely diagnosis and management to improve patient survival rates.

Area of Science:

  • Gastroenterology
  • Vascular Surgery
  • Abdominal Imaging

Background:

  • Intestinal infarction results from compromised blood flow, primarily arterial, with superior mesenteric artery emboli accounting for 50% of acute cases.
  • Arterial thrombosis often stems from atherosclerosis, while venous thrombosis is less common (5-10%) and linked to hypercoagulable states.
  • Non-occlusive ischemia, associated with shock or cardiac issues, comprises up to 25% of acute mesenteric infarction.

Purpose of the Study:

  • To analyze treatment strategies and outcomes for patients diagnosed with intestinal infarction.
  • To evaluate the efficacy of various surgical interventions and diagnostic imaging in managing acute mesenteric ischemia.

Main Methods:

  • A cohort of 19 patients with intestinal infarction treated between 2002 and 2007 underwent diagnostic imaging, including X-ray (RX) and computed tomography (CT).
  • Preoperative arteriography and multislice angio-CT were utilized in a subset of patients.
  • Second look laparotomy was performed to assess treatment effectiveness.

Main Results:

  • Surgical interventions included superior mesenteric artery embolectomy (10.5%), intestinal artery revascularization with bypass (10.5%), and resection with anastomosis (78.9%).
  • A second look laparotomy was necessary in 26% of resection cases.
  • Successful recanalization of the superior mesenteric artery was confirmed by completion angiography.

Conclusions:

  • Mesenteric ischemia, though uncommon, carries a significant mortality rate.
  • Surgical management, including revascularization and resection, can alleviate symptoms and improve outcomes.
  • A 3-month survival rate of 36.8% was observed in the studied patient cohort.
Abstract

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