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Water as biocatalyst in cytochrome P450

Devesh Kumar1, Ahmet Altun, Sason Shaikh

  • 1Max-Planck-Lnstitut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim, Germany.

Faraday Discussions
|February 17, 2011
PubMed
Summary

A single water molecule significantly lowers the energy barrier for camphor hydroxylation in cytochrome P450 enzymes. This effect, observed across various substrates, stems from enhanced hydrogen bonding in the transition state.

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