Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood and Nerve Supply to the Bones

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Hemodialysis II: Procedure and Complications

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

IgA Subclasses and Free Light Chains in Celiac Disease: A Pilot Study.

International journal of molecular sciences·2026

Same author

Neural representations of perceived engagement during action observation.

NeuroImage·2026

Same author

Outpatient Versus Inpatient Azacitidine Plus Venetoclax Regimen in Elderly Acute Myeloid Leukemia: A Multicenter Retrospective Analysis.

European journal of haematology·2025

Same author

Correction: Real-world multicenter analysis of CPX-351 efficacy in patients aged less than 60 years with secondary acute myeloid leukemia.

Blood cancer journal·2025

Same author

Cellular senescence in the innervated niche modulates cancer-associated pain: an emerging therapeutic target?

Frontiers in immunology·2025

Same author

The Strange Case of Functional High-Risk Multiple Myeloma Patients: Is It Possible to Identify Them in Clinical Practice?

Cancers·2025

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Homing of Hematopoietic Cells to the Bone Marrow

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Pain in malignant hematology.

Pasquale Niscola¹, Andrea Tendas, Laura Scaramucci

¹Hematology Unit, S. Eugenio Hospital, Rome, Italy. pniscola@gmail.com

Expert Review of Hematology

|February 17, 2011

Summary

Pain is common in hematological malignancies but often overlooked. Effective management requires a multidisciplinary approach, addressing various causes for optimal patient relief.

Related Experiment Videos

Last Updated: Jun 4, 2026

Homing of Hematopoietic Cells to the Bone Marrow

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

Area of Science:

Oncology
Pain Medicine
Hematology

Background:

Pain is a prevalent yet often under-addressed symptom in patients with hematological malignancies.
Multiple factors contribute to pain, including the malignancy itself, complications, iatrogenic causes, and unrelated conditions.

Purpose of the Study:

To highlight the significance of pain management in hematological malignancies.
To discuss the diverse etiologies and mechanisms of pain in this patient population.
To outline a comprehensive approach to pain assessment and treatment.

Main Methods:

Review of underlying causes and pathogenetic mechanisms of pain in hematological malignancies.
Discussion of a multidisciplinary approach integrating analgesics and causal interventions.
Application of the World Health Organization's (WHO) three-step analgesic scale.

Main Results:

Pain in hematological malignancies stems from various sources, necessitating tailored interventions.
A multidisciplinary strategy combining pharmacotherapy and causal treatments is crucial.
The WHO analgesic scale offers a framework for managing most cancer pain effectively.

Conclusions:

Accurate diagnosis and understanding of pain mechanisms guide effective treatment strategies.
While the WHO scale is beneficial, complex pain syndromes may require advanced management.
Integrated care is essential for improving the quality of life for patients with hematological malignancies experiencing pain.