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Mortality associated with ischaemic hepatitis.

P E Hickman1, J M Potter

  • 1Department of Biochemistry, Royal Perth Hospital, WA.

Australian and New Zealand Journal of Medicine
|February 1, 1990
PubMed
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Ischaemic hepatitis, a liver condition causing high aspartate aminotransferase (AST) levels, affected 29 inpatients. This condition is more common than expected and linked to a poor prognosis, with over half of affected patients dying.

Area of Science:

  • Hepatology
  • Clinical Medicine
  • Biochemistry

Background:

  • Ischaemic hepatitis is a severe liver injury caused by insufficient blood flow.
  • Elevated aspartate aminotransferase (AST) activity, specifically >1,000 U/L, can indicate significant liver damage.
  • The incidence and prognostic implications of ischaemic hepatitis in hospitalized patients require further elucidation.

Purpose of the Study:

  • To determine the incidence of ischaemic hepatitis among inpatients with markedly elevated AST levels.
  • To assess the mortality rate associated with ischaemic hepatitis in this population.
  • To identify the primary causes of mortality in patients diagnosed with ischaemic hepatitis.

Main Methods:

  • Retrospective analysis of inpatient admissions over a six-month period.

Related Experiment Videos

  • Identification of patients with peak aspartate aminotransferase (AST) activity >1,000 U/L.
  • Review of patient records to determine the cause of elevated AST and patient outcomes.

    • Main Results:

    • Twenty-nine of 18,000 inpatient admissions (0.16%) developed ischaemic hepatitis with peak AST >1,000 U/L.
    • Ischaemic hepatitis was the most frequent cause (56%) of AST >1,000 U/L in the studied population.
    • The overall mortality rate for these 29 patients was 58.6% (17 deaths).

    Conclusions:

    • Ischaemic hepatitis is a significant and potentially underrecognized cause of severe liver enzyme elevation in hospitalized patients.
    • The condition carries a high mortality rate, although death is typically attributed to underlying conditions rather than the hepatitis itself.
    • Early recognition and management of conditions predisposing to ischaemic hepatitis are crucial for improving patient outcomes.