Immunobiology of induced testis tumor

Teratocarcinoma of the testis has been induced in the syngeneic mouse system by transplantation of embryonic genital ridges into the testes of adult mice. The regional lymph nodes of tumor-bearing animals were found to be enlarged and hyperplastic but free of tumor cells four weeks after tumor induction. The lymphocytes obtained from these lymph nodes are capable of inducing immunity against the induction of tumor when injected into a group of adult syngeneic mice. The tumor-associated antigen and in vitro cytotoxicity are being studied in our laboratory.