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Updated: Jun 4, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Comparison of immersion ultrasound, partial coherence interferometry, and low coherence reflectometry for ocular
Robert Montés-Micó1, Francesco Carones, Antonietta Buttacchio
1Department of Optics, University of Valencia, Valencia, Spain. robert.montes@uv.es
Purpose:
To compare ocular biometry parameters measured with immersion ultrasound, partial coherence interferometry, and low coherence reflectometry in cataract patients.
Methods:
Measurements of axial length and anterior chamber depth were analyzed and compared using immersion ultrasound, partial coherence interferometry, and low coherence reflectometry. Keratometry (K), flattest axis, and white-to-white measurements were compared between partial coherence interferometry and low coherence reflectometry. Seventy-eight cataract (LOCS II range: 1 to 3) eyes of 45 patients aged between 42 and 90 years were evaluated. A subanalysis as a function of cataract degree was done for axial length and anterior chamber depth between techniques.
Results:
No statistically significant differences were noted for the study cohort or within each cataract degree among the three techniques for axial length and anterior chamber depth (P>.05, ANOVA test). Measurements between techniques were highly correlated for axial length (R=0.99) and anterior chamber depth (R=0.90 to 0.96) for all methods. Keratometry, flattest axis, and white-to-white measurements were comparable (paired t test, P>.1) and correlated well between partial coherence interferometry and low coherence reflectometry (K1 [R=0.95), K2 [R=0.97], flattest axis [R=0.95], and white-to-white [R=0.92]).
Conclusions:
Immersion ultrasound, partial coherence interferometry, and low coherence reflectometry provided comparable ocular biometry measurements in cataractous eyes.
