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Updated: Jun 4, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Coumarin-based thiol chemosensor: synthesis, turn-on mechanism, and its biological application
Hyo Sung Jung1, Kyoung Chul Ko, Gun-Hee Kim
1Department of Chemistry, Korea University, Seoul, 136-704, Korea.
Abstract:
A new chemodosimetric probe (1) is reported that selectively detects thiols over other relevant biological species by the turning on of its fluorescence through a Michael type reaction. The fluorogenic process upon its reaction was revealed to be mediated by intramolecular charge transfer, as confirmed by time-dependent density functional theory calculations. The application of probe 1 to cells is also examined by confocal microscopy, and its cysteine preference was observed by an ex vivo LC-MS analysis of the cellular metabolite.

