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Related Experiment Video

Updated: Jun 4, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Urticaria and thyroid autoimmunity.

Marcello Bagnasco¹, Paola L Minciullo, Giovanna S Saraceno

¹Terapia Medica e Radiometabolica, Dipartimento di Patologie Immunoendocrinologiche, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. bagnasco@unige.it

Thyroid : Official Journal of the American Thyroid Association

|February 18, 2011

Summary

This summary is machine-generated.

Chronic idiopathic urticaria (CIU) is often linked to autoimmune thyroid diseases. Approximately 25% of CIU patients show thyroid autoimmunity, suggesting a connection that warrants further investigation.

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Published on: December 15, 2011

Area of Science:

Immunology
Endocrinology
Dermatology

Background:

Chronic idiopathic urticaria (CIU) affects many individuals, with unknown causes in about 75% of cases.
A potential association between CIU and autoimmune thyroid diseases has been hypothesized for decades.

Purpose of the Study:

To review the existing literature on the association between chronic idiopathic urticaria and autoimmune thyroid diseases.
To evaluate the evidence supporting the link between CIU and thyroid autoimmunity.

Main Methods:

Review of multiple studies investigating the relationship between CIU and autoimmune thyroid conditions.
Analysis of serological evidence for thyroid autoimmunity in CIU patients.

Main Results:

Approximately one-fourth of patients with CIU exhibit serological evidence of thyroid autoimmunity.
Many studies examining this association lack robust controls, limiting definitive conclusions.
Current data does not correlate CIU with histological findings of autoimmune thyroiditis or hypothyroidism.

Conclusions:

Screening for thyroid autoimmunity in CIU patients is likely beneficial.
Further well-controlled studies are needed to confirm the association and explore potential therapeutic roles for L-thyroxine in managing urticaria symptoms.