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Related Concept Videos

Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Inhalational Anesthetics: Overview01:20

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Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...

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Related Experiment Video

Updated: Jun 4, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

Defining awakening from anesthesia in neonates: a consensus study.

Matthew D Bould1, Michael R J Sury

  • 1Department of Anesthesiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Paediatric Anaesthesia
|February 18, 2011
PubMed
Summary

Experts reached consensus on a new definition for awakening in neonates after anesthesia. This scale, using specific behaviors and stimuli, aids in monitoring anesthesia depth and electroencephalographic data.

Related Experiment Videos

Last Updated: Jun 4, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers
14:52

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

Area of Science:

  • Anesthesiology
  • Neonatal Care
  • Pediatric Medicine

Background:

  • Developing a reliable tool to assess neonatal awakening post-anesthesia is crucial for evaluating anesthesia depth monitoring.
  • Existing scales for children and infants are not applicable to anesthetized neonates.
  • Expert consensus was sought to define awakening in this specific population.

Purpose of the Study:

  • To achieve expert consensus on a definition for awakening in neonates at the conclusion of anesthesia.
  • To establish criteria and stimuli for assessing neonatal emergence from anesthesia.

Main Methods:

  • A modified Delphi technique involving iterative questionnaires and anonymized feedback via email was employed.
  • Thirty-one consultant pediatric anesthetists from the UK and Ireland participated.
  • Consensus was predefined as 80% agreement among participants.

Main Results:

  • 83% of experts agreed that defining neonatal awakening is feasible.
  • Consensus was achieved on six criteria, requiring a combination for assessment.
  • A proposed definition for awakening includes at least two of five behaviors (crying/attempting to cry, vigorous limb movements, gagging on tracheal tube, eyes open, looking around).
  • Consensus was also reached on three appropriate stimuli to test rousability: removal of adhesive tape, skin stimulation, and pharyngeal suction.

Conclusions:

  • A proposed scale for determining awakening in neonates after anesthesia is presented.
  • This scale can be utilized in future research, particularly for electroencephalographic and anesthesia depth monitoring in neonates.