Related Experiment Video
Updated: Jun 4, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
Sexual orientation and its relation to mental disorders and suicide attempts: findings from a nationally
Shay-Lee Bolton1, Jitender Sareen
1Department of Community Health Sciences and Research Associate, Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba. sbelik@hsc.mb.ca
Objective:
To compare the rates of all Axis I and II mental disorders and suicide attempts in sexual orientation minorities with rates in heterosexuals using a nationally representative sample.
Method:
Data used were from the National Epidemiologic Survey on Alcohol and Related Conditions Wave 2 (n = 34 653, response rate = 70.2%). Cross-tabulations and multivariate logistic regression analyses were performed to determine differences in rates of mental disorders and suicide attempts by sexual orientation. All analyses were stratified by sex.
Results:
Compared with their heterosexual counterparts, lesbians and bisexual women demonstrated a 3-fold increased likelihood of substance use disorders, and gay and bisexual men showed twice the rate of anxiety disorders and schizophrenia and (or) psychotic illness, even after accounting for mental disorder comorbidity. Suicide attempts were independently associated with bisexuality, with odds 3 times higher than in heterosexuals.
Conclusion:
Findings from our study emphasize the fact that sexual orientation minorities are vulnerable to poor mental health outcomes, including suicide attempts. Clinicians need to be aware of these specific negative mental health consequences when assessing sexual orientation minorities.
Related Concept Videos
Amebiasis
Sex Linked Disorders
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Psychological and Sociocultural Causes of Schizophrenia
