Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-term outcomes in radiofrequency ablation for the primary treatment of T1N0M0 papillary thyroid carcinomas.

American journal of surgery·2025
Same author

Utility of Parathyroid Autofluorescence in Differentiating Parathyroid Pathology.

World journal of surgery·2025
Same author

Analysis of Heavy Metal Pollution in the Water of the Halda River: A Distinctive Breeding Habitat for Carp Fish in Bangladesh.

Veterinary medicine and science·2024
Same author

Machine learning-derived clinical decision algorithm for the diagnosis of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism.

European radiology·2024
Same author

Improvement in thyroid-specific quality of life following radiofrequency ablation of benign thyroid nodules: A USA study.

Surgery·2024
Same author

Radiofrequency ablation of Bethesda category III thyroid nodules with benign molecular testing: Preliminary findings from a single institution.

American journal of surgery·2024
Same journal

Tirzepatide versus conventional GLP-1 receptor agonists for treatment simplification in type 2 diabetes mellitus: a real-world study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Risk-stratification of pediatric thyroid nodules using ATA and ACR TIRADS adult thyroid nodule scoring systems.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Effectiveness of GLP-1 receptor agonists and SGLT-2 inhibitors combination therapy in type 2 diabetes: a real world experience.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

North American Society for Interventional Thyroidology (NASIT) Statement on Directed Ablative Therapy for the Management of of Low Risk Papillary Thyroid Carcinoma.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Lower Cutoffs Improve the Diagnostic Performance of DDAVP-Stimulated Bilateral Inferior Petrosal Sinus Sampling for Cushing Disease: A Prospective Cohort Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same journal

Efficacy of Initiation of Semaglutide versus SGLT2 inhibitors in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Multicenter Propensity-Matched Real-World Study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Calciphylaxis due to hyperparathyroidism.

Rashmi Roy1, James A Lee

  • 1Department of Endocrine Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA. rroy2@jhmi.edu

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|February 18, 2011
PubMed
Summary
This summary is machine-generated.

Early diagnosis and treatment of calciphylaxis, a condition involving calcium-phosphate deposits, are critical. Surgical intervention, such as parathyroidectomy, can be life-saving when medical management fails.

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Related Experiment Videos

Last Updated: Jun 4, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Area of Science:

  • Nephrology
  • Endocrinology
  • Dermatology

Background:

  • Calciphylaxis is a rare and severe condition characterized by vascular calcification and skin necrosis.
  • It is often associated with chronic kidney disease and secondary or tertiary hyperparathyroidism, but can occur in primary hyperparathyroidism.
  • Pathologically, it results from calcium-phosphate deposition in small arteries, leading to ischemia and painful lesions.

Purpose of the Study:

  • To outline the diagnostic workup for calciphylaxis.
  • To differentiate between medical and surgical management strategies.
  • To emphasize the importance of early detection and multidisciplinary care.

Main Methods:

  • A review of evidence-based medical literature.
  • Focus on calciphylaxis associated with primary, secondary, and tertiary hyperparathyroidism.

Main Results:

  • Calciphylaxis typically occurs with secondary/tertiary hyperparathyroidism but can be seen in primary hyperparathyroidism.
  • Diagnosis relies on physical examination, lab results, and histopathology.
  • Parathyroidectomy is preferred for secondary/tertiary hyperparathyroidism when medical therapy fails; gland resection is crucial in primary hyperparathyroidism.

Conclusions:

  • Early diagnosis of calciphylaxis is essential for successful management.
  • While medical therapy is important, surgical resection of affected parathyroid glands offers a curative and potentially life-saving option.
  • A comprehensive approach including early diagnosis, medical management, surgical debridement, and parathyroidectomy improves survival rates.