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Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...

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Related Experiment Video

Updated: Jun 4, 2026

Tissue Engineering of a Human 3D in vitro Tumor Test System
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Tissue Engineering of a Human 3D in vitro Tumor Test System

Published on: August 6, 2013

Tissue engineering of human bladder.

Anthony Atala1

  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. aatala@wfubmc.edu

British Medical Bulletin
|February 18, 2011
PubMed
Summary
This summary is machine-generated.

Tissue engineering offers promising alternatives for bladder reconstruction, potentially improving outcomes. Current research favors using biomaterial scaffolds with patient

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Area of Science:

  • Regenerative Medicine
  • Urology
  • Biomaterials Science

Background:

  • Bladder dysfunction necessitates reconstructive procedures, often with complications.
  • Current reconstructive techniques have limitations and potential adverse outcomes.
  • Tissue engineering aims to create functional bladder tissues for improved surgical results.

Purpose of the Study:

  • To review literature on tissue engineering for bladder reconstruction.
  • To identify evidence supporting tissue-engineered alternatives to current methods.
  • To assess the feasibility and limitations of laboratory-created bladder tissues.

Main Methods:

  • PubMed literature search for tissue engineering in bladder reconstruction.
  • Analysis of animal studies and clinical experiences.
  • Evaluation of cell sources and scaffold materials.

Main Results:

  • Animal and clinical studies demonstrate successful bladder reconstruction using engineered tissues.
  • Non-autologous cells present rejection challenges, limiting their use.
  • Biomaterial scaffolds seeded with autologous urothelial and smooth muscle cells show promise.

Conclusions:

  • Tissue engineering holds potential for improved bladder reconstruction.
  • Autologous cell-seeded biomaterial scaffolds represent the current optimal approach.
  • Further research into novel biomaterials, cell sources, and biological mechanisms is needed.