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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Published on: August 1, 2025

The "new" marijuana.

Daina L Wells1, Carol A Ott

  • 1Department of Mental Health, Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC, USA. Daina.Wells@va.gov

The Annals of Pharmacotherapy
|February 18, 2011
PubMed
Summary
This summary is machine-generated.

Synthetic cannabinoid toxicity is rising, with over 1057 cases reported by August 2010. This review covers synthetic cannabinoid development, abuse, toxicity, and treatment for healthcare professionals.

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Area of Science:

  • Toxicology
  • Emergency Medicine
  • Pharmacology

Background:

  • Synthetic cannabinoid use and associated toxicity are increasing nationwide.
  • Over 1057 cases of synthetic cannabinoid toxicity were reported by August 2010.
  • Limited literature exists on synthetic cannabinoid toxicity, despite reported adverse effects.

Purpose of the Study:

  • To review the development, abuse, toxicity, treatment, and legal status of synthetic cannabinoids.
  • To inform healthcare professionals about recognizing and managing synthetic cannabinoid-induced toxicity.
  • To address the growing concern regarding acute and long-term toxicities.

Main Methods:

  • Literature review of synthetic cannabinoid development, abuse, and toxicity.
  • Analysis of reported adverse effects and case studies.
  • Examination of current treatment strategies and legal status.

Main Results:

  • Adverse effects include tachycardia, hypertension, tachypnea, chest pain, palpitations, hallucinations, racing thoughts, and seizures.
  • Toxic symptoms typically resolve within 3-4 hours, often without residual effects.
  • Concerns remain regarding potential serious acute and long-term toxicities.

Conclusions:

  • Healthcare professionals must be prepared to recognize and treat synthetic cannabinoid toxicity.
  • Further research is needed to fully understand the scope of synthetic cannabinoid-induced adverse effects.
  • Awareness and appropriate management are crucial due to the increasing prevalence of synthetic cannabinoid abuse.