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Updated: Jun 4, 2026
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Role of phytosterols in lipid-lowering: current perspectives
A K Gupta1, C G Savopoulos, J Ahuja
1International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College London, 59-61 North Wharf Road, London, UK. a.k.gupta@imperial.ac.uk
QJM : Monthly Journal of the Association of Physicians
|February 18, 2011
Summary
Plant sterols effectively lower cholesterol. Incorporating sterol-rich foods enhances lipid-lowering diets and therapies for most patients with dyslipidemia.
Area of Science:
- Nutritional Science
- Cardiovascular Health
Background:
- Plant sterols, known for cholesterol-lowering properties since the 1950s, are now clinically relevant due to food technology advancements.
- Fortification of various food products (margarines, yogurts, juices, bars) with plant sterols has increased accessibility.
Purpose of the Study:
- To review clinical trial evidence on the lipid-lowering efficacy of plant sterols.
- To discuss the implications of plant sterol use in routine clinical practice.
Main Methods:
- Searched the PubMed database for English language literature.
- Utilized relevant keywords and Medical Subject Heading (MeSH) terms.
- Extracted findings from recent studies and meta-analyses.
Main Results:
- Short-term use of plant sterol-rich food supplements is safe and effective.
- Plant sterols enhance the benefits of dietary and lifestyle therapy.
- They provide additional lipid-lowering effects, with or without statin therapy.
Conclusions:
- Plant sterols are a valuable addition to lipid-lowering strategies for dyslipidemic patients.
- Their integration into functional foods facilitates clinical application.
- They offer a safe and effective option for managing dyslipidemia.
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