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Updated: Jun 4, 2026
08:56
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
Cancer-related fatigue: a practical review
M P O Campos1, B J Hassan2, R Riechelmann3
1Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami.
Summary
Cancer-related fatigue is common and treatable, affecting 50-90% of patients. Addressing underlying causes and using tailored interventions can significantly improve quality of life for cancer survivors.
Area of Science:
- Oncology
- Palliative Care
- Quality of Life Research
Background:
- Cancer-related fatigue (CRF) is a prevalent and debilitating symptom affecting 50-90% of cancer patients.
- CRF significantly impacts all aspects of a patient's quality of life.
- Existing barriers include physician knowledge gaps and patient reluctance to report fatigue.
Purpose of the Study:
- To provide a practical review for healthcare professionals on managing cancer-related fatigue.
- To highlight common barriers to fatigue treatment in cancer care.
- To emphasize the importance of regular fatigue screening and tailored interventions.
Main Methods:
- Review of existing literature on cancer-related fatigue prevalence, contributing factors, and management strategies.
- Identification of reversible causes of fatigue (e.g., anemia, hypothyroidism, pain, distress).
- Discussion of pharmacologic and nonpharmacologic interventions based on fatigue severity.
Main Results:
- Addressing reversible factors is a crucial first step in managing CRF.
- Regular screening using validated tools is recommended for all cancer patients.
- Interventions should be tailored: pharmacologic and nonpharmacologic for moderate/severe fatigue, nonpharmacologic for mild fatigue.
Conclusions:
- Effective management of cancer-related fatigue requires addressing both medical and psychosocial aspects.
- Overcoming physician and patient-related barriers is essential for optimal CRF treatment.
- A systematic approach to screening and intervention can improve patient outcomes and quality of life.
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