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Updated: Jun 4, 2026

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Comment on "Multidimensional results reporting to participants in genomic studies: getting it right"
Science Translational Medicine
|February 18, 2011
Summary
The National Heart, Lung, and Blood Institute (NHLBI) report recommends returning genetic results to research participants when interventions exist. It does not prohibit returning results when no intervention is available.
Area of Science:
- Genetics
- Bioethics
- Public Health
Background:
- Clarification of National Heart, Lung, and Blood Institute (NHLBI) guidelines on returning research genetic findings.
- Addressing misinterpretations regarding the conditions under which genetic information should be disclosed to research participants.
Discussion:
- The NHLBI Working Group report on Reporting Genetic Results in Research Studies provides nuanced recommendations.
- The report supports returning genetic information when interventions are available for identified disorders.
Key Insights:
- The NHLBI report does not restrict the return of genetic information solely to cases with available interventions.
- Genetic research findings can be shared with participants even if no immediate therapeutic or preventative options exist.
Outlook:
- Promoting ethical and transparent communication in genetic research.
- Ensuring participants receive relevant genetic information to inform their health decisions.
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