Related Experiment Video
Updated: Jun 4, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions
Prakash Saha1, Julia Humphries, Bijan Modarai
1Kings College London, British Heart Foundation Centre of Research Excellence and National Institute for Health Research Biomedical Research Centre at Kings Health Partners, Academic Department of Surgery, St Thomas' Hospital, London, United Kingdom.
Abstract:
Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis I: Introduction
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis IV: Nursing Management
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Pulmonary Embolism I: Introduction

