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Updated: Jun 4, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Immediate effect on overactive bladder symptoms following administration of imidafenacin
Yasuhide Kitagawa1, Masato Kuribayashi, Kazutaka Narimoto
1Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa, Ichikawa, Japan. yasukita@med.kanazawa-u.ac.jp
Introduction:
One of the factors influencing the treatment compliance of patients with overactive bladder (OAB) symptoms is thought to be the time to reach clinical effectiveness after administering drugs. We investigated the immediate effect of imidafenacin on OAB symptoms.
Patients And Methods:
Imidafenacin (0.1 mg) was administered. OAB symptom scores (OABSS) were evaluated before administration, and at 2 and 4 weeks after administration. The subjective efficacy in patients was examined by recording daily changes for 2 weeks.
Results:
Twenty patients were evaluated for efficacy using OABSS and uroflowmetry with postvoid residual volume. Nineteen patients completely recorded daily changes in subjective efficacy. The mean total OABSS decreased gradually during 2 weeks after administration. Patients reported the drug's efficacy to begin 3 days after the commencement of administration. Urinary flow and postvoid residual volume did not change after administration.
Conclusion:
The subjective efficacy of imidafenacin was observed from 3 days after the commencement of administration.
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