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Updated: Jun 4, 2026

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
Prognostic significance of interleukin-7 receptor-α gene polymorphisms in allogeneic stem-cell transplantation: a
Zaiba Shamim1, Lars P Ryder, Ib J Christensen
1Department of Clinical Immunology, Section 7631, University Hospital Rigshospitalet, Copenhagen, Denmark.
Background:
Interleukin-7 (IL-7) is a hematopoietic cytokine essential for T-cell development in the thymus and for the maintenance of peripheral T cells. A previous study of single nucleotide polymorphisms in the exons of IL-7 receptor α-chain (IL-7Rα) in a Danish cohort of patients undergoing allogeneic stem-cell transplantation (SCT) identified donor genotype GG at rs1494555 as a risk factor for treatment-related mortality (TRM) after SCT.
Methods:
In this validation study, 116 British and French SCT patients and their donors were investigated by sequence-specific primer polymerase chain reaction.
Results:
Both donor rs1494555GG genotype and the tightly coupled rs1494558TT genotype were significantly associated with grade 3 to 4 acute graft versus host disease. Although both genotypes tended to be associated with increased TRM, this did not translate into altered overall survival.
Conclusion:
The present data indicate that the IL-7 pathway is associated with alloreactivity in SCT, which is in line with the previously observed association between IL-7Rα single nucleotide polymorphisms and TRM.
