Creatine excretion in urine of man under hypokinesia and physical exercise

It is known that hypokinesia (diminished muscular activity) induces changes in various biochemical parameters of the organism, including creatine. Thus the aim of this study was to determine daily excretion of creatine under 100-days' exposure to hypokinesia (HK) in essentially healthy men, aged 18-23 years. They were divided into two groups with 3 men in each. The control group of men was subjected to "pure" HK i.e. without the use of any preventive measures, and the experimental group was submitted to combined HK and PE (physical exercise). For the simulation of the hypokinetic effect both groups of men were kept under a rigorous bed rest regime. Creatine excretion was calculated by conventional methods. The results obtained were analyzed statistically. In the control group of men the increased renal excretion of creatine was found in the initial 60-days' period of HK and return to the baseline level during the 60th-90th days. In the experimental group of men a reduced delayed elevation of creatine elimination in urine was manifested only during the 60th-90th days of HK. It was concluded that increased creatine excretion in urine developed during initial HK. Physical exercise may be used to attenuate creatinuria under diminished muscular activity.