Creatinine excretion in urine of man under hypokinesia and physical exercise

It was assumed that creatinine loss in urine of man may increase or decrease under hypokinesia (diminished muscular activity) and physical exercise. Thus the aim of this study was to calculate creatinine excretion in urine of 12 healthy men, aged 19-23, under 100-days' exposure to hypokinesia (HK) and PE. They were divided into two groups, with 6 men in each. The 1st group of men was subjected to pure HK and the 2nd group was submitted to combined HK and PE. For the simulation of the hypokinetic effect both groups of men were kept under 100 days of ad-libitum bedrest protocol. A full nutritions diet was given to both groups of men. The creatinine excretion in urine was measured by conventional methods. By the 18th day of hypokinesia an increase in the rate of excretion of creatinine in urine was demonstrated, and by the 55th day there was a more pronounced increase in creatinine excretion. Physical exercise failed to diminish creatinine excretion. It was concluded that hypokinesia and physical exercise increased creatinine excretion in urine of man.