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Adherence therapy for medication non-compliant patients with hypertension: a randomised controlled trial

F Alhalaiqa1, K H O Deane, A H Nawafleh

  • 1Faculty of Health, Nursing and Midwifery, University of East Anglia, Norwich, UK.

Journal of Human Hypertension
|February 18, 2011
PubMed

Insights

Adherence therapy (AT) significantly reduces blood pressure (BP) in non-compliant hypertensive patients. This intervention improves medication adherence, leading to clinically important reductions in systolic and diastolic BP.

Area of Science:

  • Cardiology
  • Clinical Pharmacy
  • Public Health

Background:

  • Hypertension is a major global health concern, often exacerbated by poor patient adherence to prescribed medication.
  • Non-compliance in hypertensive patients significantly hinders effective blood pressure management and increases cardiovascular risk.
  • Adherence therapy (AT) presents a potential strategy to improve medication adherence and subsequent blood pressure control.

Purpose of the Study:

  • To evaluate the efficacy of adherence therapy (AT) versus treatment as usual (TAU) in reducing blood pressure (BP) among non-compliant hypertensive patients.
  • To assess the impact of AT on medication adherence rates in this patient population.
  • To determine the clinical significance of BP reduction achieved through AT.

Main Methods:

  • A single-blind, parallel-group randomized controlled trial was conducted with 136 non-compliant hypertensive patients.
  • Participants received either 7 weekly 20-minute sessions of AT plus TAU, or TAU alone.
  • Blood pressure (systolic and diastolic) and medication adherence (pill counting) were measured at 11-week follow-up.

Main Results:

  • Adherence therapy significantly reduced systolic blood pressure by -23.11 mmHg and diastolic blood pressure by -15.18 mmHg compared to TAU.
  • Medication adherence, measured by pill counting, improved by 37% in the AT group at 11 weeks.
  • No significant adverse events were reported during the study period.

Conclusions:

  • Adherence therapy is an effective intervention for improving medication adherence in hypertensive patients.
  • AT leads to clinically significant reductions in both systolic and diastolic blood pressure.
  • AT represents a valuable therapeutic strategy for managing hypertension in non-compliant patients.

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