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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Breast milk and transplantation tolerance

Kazutoshi Aoyama1, Ken-Ichi Matsuoka, Takanori Teshima

  • 1Biopathological Science; Okayama University Graduate School of Medicine and Dentistry; Okayama, Japan.

Chimerism
|February 18, 2011
PubMed

Recent experimental and clinical studies suggest that exposure of the fetus to noninherited maternal antigens (NIMAs) during pregnancy has an impact on allogeneic transplantations performed later in life. We have reported that NIMA exposure by breastfeeding further potentiates the tolerogenic NIMA effect mediated by in utero NIMA exposure during pregnancy in mice of allogeneic hematopoietic stem cell transplantation (HSCT). Breastfeeding generates Foxp3(+) regulatory T cells that suppress anti-maternal immunity and persist until adulthood. These results reveal a previously unknown impact of breastfeeding on the outcome of allogeneic HSCT.

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