Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arterial and venous thromboembolism in hospitalized patients with COVID-19: a national multicenter cohort study.

Blood vessels, thrombosis & hemostasis·2026
Same author

Treatment and outcomes of thromboembolism in paediatric patients with cardiac disease in a cardiac ICU: a single-centre retrospective study.

Cardiology in the young·2026
Same author

Bleeding-related quality of life in older adults: Psychometric evaluation of the HEmorrhage Life Impact indeX (HELIX).

Thrombosis research·2026
Same author

A qualitative study of warfarin self-management in the United States healthcare system: insights from patient experiences.

Journal of thrombosis and thrombolysis·2026
Same author

Pharmacist antithrombotic interventions in critically ill children: A multicenter prospective study.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same author

Validity of ICD-10 codes for identifying gastrointestinal bleeding in anticoagulated patients: an encounter-level diagnostic accuracy study.

Journal of thrombosis and thrombolysis·2026

Related Experiment Video

Updated: Jun 4, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Quality measures and benchmarking for warfarin therapy.

Daniel M Witt1

  • 1Clinical Pharmacy Research and Applied Pharmacogenomics, Kaiser Permanente Colorado, 16601 East Centretech Parkway, Aurora, CO 80011, USA. dan.m.witt@kp.org

Journal of Thrombosis and Thrombolysis
|February 18, 2011
PubMed
Summary

Achieving optimal warfarin therapy requires efficient anticoagulation management systems. Quality measurement is crucial for effective warfarin treatment and comparing new oral anticoagulants.

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

Related Experiment Videos

Last Updated: Jun 4, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Health Services Research

Background:

  • Warfarin therapy aims to prevent thromboembolism while minimizing bleeding risk.
  • Effective warfarin management depends on the seamless functioning of anticoagulation management systems.
  • Quality measurement is essential for evaluating and improving warfarin therapy.

Purpose of the Study:

  • To highlight the need for structured quality measurement in warfarin therapy management.
  • To emphasize the importance of anticoagulation management system quality.
  • To underscore the role of management quality in evaluating new oral anticoagulants.

Main Methods:

  • Quality can be assessed through outcomes (e.g., INR, bleeding, thromboembolism, death).
  • Process measures (e.g., warfarin dose adjustment methods) are used for evaluation.
  • Structural measures (e.g., clinic organization) also inform quality assessment.

Main Results:

  • The quality of warfarin therapy management is determined by the coordination of its components.
  • There is a significant need for structured quality measurement programs.
  • High-quality warfarin management is critical for patient safety and treatment efficacy.

Conclusions:

  • Optimal warfarin therapy requires well-functioning anticoagulation management systems.
  • Structured quality measurement is vital for improving warfarin treatment outcomes.
  • Assessing warfarin management quality is increasingly important with the advent of new oral anticoagulants.