Effect of dietary protein on heme iron uptake by Caco-2 cells

Pía Villarroel1, Sebastián Flores, Fernando Pizarro

  • 1Micronutrient Laboratory, INTA, University of Chile, El Líbano 5524, 138-11, Macul, Santiago, Chile.

Abstract

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Hepatic Drug Clearance: Effect of Protein Binding01:09

Hepatic Drug Clearance: Effect of Protein Binding

Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...