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Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: Jun 4, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Oncology protocols: how can we do better?

Sue C Kaste1

  • 1St. Jude Children's Research Hospital, MSN #220, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA. Sue.kaste@stjude.org

Pediatric Radiology
|February 18, 2011
PubMed
Summary
This summary is machine-generated.

Standardizing diagnostic imaging is crucial for pediatric cancer clinical trials to accurately assess treatment effects. Optimizing imaging modalities ensures patient care while minimizing radiation exposure.

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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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Published on: January 22, 2011

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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Area of Science:

  • Medical imaging
  • Pediatric oncology
  • Clinical trial design

Background:

  • Diagnostic imaging is essential for pediatric cancer patient care and treatment assessment in clinical trials.
  • Standardization of imaging techniques, measurements, data analysis, and interpretation is vital for reliable clinical trial outcomes.

Purpose of the Study:

  • To discuss critical factors in designing pediatric oncology clinical trials using diagnostic imaging.
  • To explore methods for improving consistency in imaging data collection and interpretation.
  • To address the selection of optimal imaging modalities balancing scientific inquiry, patient care, and radiation safety.

Main Methods:

  • Review of current practices in diagnostic imaging for pediatric oncology clinical trials.
  • Discussion of standardization requirements for imaging techniques and data analysis.
  • Consideration of radiation dose optimization in imaging protocols.

Main Results:

  • Inconsistencies in current imaging practices can impact the scientific validity of clinical trial results.
  • Standardization is necessary for reproducible and reliable tumor assessment.
  • Balancing diagnostic accuracy, patient care, and radiation safety is a key challenge.

Conclusions:

  • Standardized diagnostic imaging protocols are fundamental for effective pediatric oncology clinical trials.
  • Optimizing imaging modalities and minimizing radiation exposure are critical considerations for future research.
  • Addressing current inconsistencies will enhance the scientific decision-making process for treatment regimens.