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Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jun 4, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

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Published on: May 3, 2018

What's the hype about CDK5RAP2?

Nadine Kraemer1, Lina Issa, Stefanie C R Hauck

  • 1Department of Pediatric Neurology, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Cellular and Molecular Life Sciences : CMLS
|February 18, 2011
PubMed
Summary
This summary is machine-generated.

Mutations in Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) cause primary autosomal recessive microcephaly, a brain developmental defect. Understanding CDK5RAP2 function offers insights into brain development and evolution.

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12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) mutations cause primary autosomal recessive microcephaly.
  • This condition is an isolated brain developmental defect, primarily affecting the cerebral cortex.
  • CDK5RAP2's role is crucial for understanding human brain development and evolution, especially cortical expansion in primates.

Purpose of the Study:

  • To provide an overview of CDK5RAP2 functions.
  • To explore the mechanisms underlying human diseases caused by CDK5RAP2 dysfunction.
  • To connect CDK5RAP2's role to broader concepts in brain development and evolution.

Main Methods:

  • Literature review of studies on CDK5RAP2.
  • Analysis of genetic data related to microcephaly.
  • Synthesis of current knowledge on protein function and disease mechanisms.

Main Results:

  • CDK5RAP2 is essential for normal brain development, particularly cerebral cortex formation.
  • Recessive mutations in CDK5RAP2 lead to primary autosomal recessive microcephaly.
  • The protein's function is implicated in the evolutionary increase of cerebral cortex size in mammals.

Conclusions:

  • CDK5RAP2 plays a critical role in human brain development.
  • Understanding CDK5RAP2 dysfunction illuminates the pathogenesis of microcephaly.
  • Research on CDK5RAP2 contributes to understanding cortical evolution.