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Updated: Jun 4, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
[Mononeuritis multiplex under the TNF-alpha inhibitor infliximab]
N Bandelow1, M Wiederkehr, P Hasler
1Rheumatologie, Kantonsspital Aarau, Tellstrasse, Aarau. norman.bandelow@ksa.ch
Abstract:
A 21-year-old patient with ankylosing spondylitis under treatment with the TNF-alpha inhibitor infliximab developed a multifocal, demyelinating axonal neuropathy affecting several peripheral nerves simultaneously (mononeuritis multiplex). This represents an additional rare peripheral nervous system side effect of infliximab therapy. The underlying cause is unknown. Intravenous immunoglobulin therapy (0.4 g/kg per day for five days) led to a complete regression of muscle paresis and sensory defects in this case.
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