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Related Experiment Video

Updated: Jun 4, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

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Intermittent pneumatic compression for treating venous leg ulcers.

E Andrea Nelson¹, Raj Mani, Kate Thomas

¹School of Healthcare, University of Leeds, Baines Wing, Leeds, UK, LS2 9UT.

The Cochrane Database of Systematic Reviews

|February 18, 2011

Summary

Intermittent pneumatic compression (IPC) may improve venous leg ulcer healing compared to no compression. However, its effectiveness when added to bandages or used alone requires further investigation.

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Area of Science:

Vascular Medicine
Wound Healing
Medical Devices

Background:

Intermittent pneumatic compression (IPC) is a mechanical compression method for swollen limbs.
It is utilized in treating venous leg ulcers and lymphoedema-related swelling.

Purpose of the Study:

To evaluate if IPC enhances venous leg ulcer healing.
To assess the impact of IPC on the quality of life for venous leg ulcer patients.

Main Methods:

Systematic review of randomized controlled trials (RCTs) comparing IPC with control or different IPC regimens.
Searches conducted across multiple databases including Cochrane, MEDLINE, EMBASE, and CINAHL up to December 2010.

Main Results:

Seven RCTs involving 367 participants were identified; only one had a low risk of bias.
One trial showed significantly higher ulcer healing with IPC versus dressings (62% vs 28%).
Evidence on IPC added to compression bandages was conflicting, with one trial showing benefit and three showing none. Rapid IPC demonstrated better healing than slow IPC in one study.

Conclusions:

IPC might enhance healing over no compression, but its benefit with bandages or as a replacement is uncertain.
Rapid IPC appears more effective than slow IPC.
Further research is needed to confirm IPC's efficacy in contemporary clinical practice with widespread compression therapy.