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Related Experiment Video

Updated: Jun 4, 2026

Whole Body Vibration Methods with Survivors of Polio
04:16

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

Treatment for postpolio syndrome.

Fieke Sophia Koopman1, Kimi Uegaki, Nils Erik Gilhus

  • 1Department of Rehabilitation, University of Amsterdam Academic Medical Center, PO Box 22660, Amsterdam, North Holland, Netherlands, 1100 DD.

The Cochrane Database of Systematic Reviews
|February 18, 2011
PubMed
Summary
This summary is machine-generated.

Postpolio syndrome (PPS) treatments lack definitive evidence due to limited high-quality studies. Intravenous immunoglobulin, lamotrigine, muscle strengthening, and magnetic fields show potential but require further research for PPS management.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Postpolio syndrome (PPS) affects polio survivors, causing neuromuscular symptoms and functional decline.
  • The efficacy of current pharmacological and rehabilitation interventions for PPS remains unestablished.

Purpose of the Study:

  • To systematically review the effectiveness of various treatments for Postpolio Syndrome (PPS) compared to placebo, usual care, or no treatment.

Main Methods:

  • Searched multiple databases (Cochrane, MEDLINE, EMBASE, PsycINFO, CINAHL) up to September 2010.
  • Included randomized and quasi-randomized trials of pharmacological and non-pharmacological PPS treatments.
  • Assessed outcomes including activity limitations, muscle strength, fatigue, pain, and adverse events.

Main Results:

  • Nine pharmacological and three non-pharmacological studies were reviewed, with most having a risk of bias (lack of blinding).
  • Intravenous immunoglobulin showed no benefit for activity limitations; evidence for muscle strength and pain was inconsistent.
  • Lamotrigine showed very low-quality evidence for reducing pain and fatigue. Muscle strengthening and static magnetic fields suggested benefits for muscle strength and pain, respectively, with low-quality evidence.

Conclusions:

  • Insufficient high-quality randomized data prevents definitive conclusions on PPS interventions.
  • Intravenous immunoglobulin, lamotrigine, muscle strengthening, and static magnetic fields may offer benefits but require further investigation.