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Updated: Jun 4, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
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Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

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[Percutaneous aortic valve implantation].

Arie Pieter Kappetein1, Felix Zijlstra

  • 1Erasmus Medisch Centrum, Thoraxcentrum, Rotterdam, Netherlands.

Nederlands Tijdschrift Voor Geneeskunde
|February 19, 2011
PubMed
Summary
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Transcatheter aortic valve replacement offers a less invasive option for aortic stenosis patients with high surgical risk. Further trials are needed to confirm long-term outcomes and cost-effectiveness.

Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Bioprosthetic valve technology

Context:

  • Degenerative and calcific aortic stenosis increasingly affects an aging population.
  • High-risk comorbidities limit surgical aortic valve replacement options.
  • Advancements in catheter technology enable less invasive valve delivery.

Purpose:

  • To evaluate the efficacy and safety of transcatheter aortic valve replacement (TAVR) as an alternative to surgical aortic valve replacement (SAVR).
  • To present early findings from a randomized trial comparing TAVR and SAVR.
  • To highlight the potential of TAVR in managing aortic stenosis in high-risk patients.

Summary:

  • Surgical aortic valve replacement is effective but poses high risks for elderly patients with comorbidities.

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Published on: December 11, 2017

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Published on: June 8, 2022

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
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Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

  • Transcatheter aortic valve replacement (TAVR) via femoral artery or transapical routes offers a less invasive alternative.
  • Initial results from a randomized trial show promise for TAVR, indicating a new era in valvular heart disease treatment.

    • Impact:

    • TAVR provides a viable, less invasive treatment option for patients with severe aortic stenosis who are poor surgical candidates.
    • The study underscores the need for extensive, long-term randomized trials to assess TAVR's mortality, morbidity, and cost-effectiveness.
    • This research paves the way for broader adoption of TAVR, potentially transforming valvular heart disease management.