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Effects of peritoneal dialysis and hemodialysis on arterial stiffness compared with predialysis patients

L Yang1, Y Lin, C Ye

  • 1Department of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Clinical Nephrology
|February 19, 2011
PubMed

Insights

Arterial stiffness worsens with declining kidney function in chronic kidney disease (CKD). Dialysis, including peritoneal dialysis and hemodialysis, can significantly improve arterial stiffness in CKD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Arterial stiffness is a significant complication in chronic kidney disease (CKD).
  • The relationship between glomerular filtration rate (GFR) and arterial stiffness in CKD requires further investigation.
  • The impact of dialysis modalities on arterial stiffness in CKD patients is not fully understood.

Purpose of the Study:

  • To investigate the association between GFR and arterial stiffness in CKD patients.
  • To evaluate the effect of dialysis (peritoneal dialysis and hemodialysis) on arterial stiffness.

Main Methods:

  • A cross-sectional study involving 62 continuous ambulatory peritoneal dialysis (CAPD) patients, 56 hemodialysis patients, 128 predialysis CKD patients, and 40 healthy controls.
  • Nondiabetic participants comparable in age and gender were included.
  • Arterial stiffness was assessed using pulse wave velocity (PWV) and augmentation index (AIx) measured by applanation tonometry.

Main Results:

  • Arterial stiffness (PWV and AIx) was negatively correlated with GFR in predialysis CKD patients.
  • Patients undergoing dialysis (peritoneal or hemodialysis) exhibited improved PWV and AIx compared to predialysis CKD 5 patients.
  • No significant difference in arterial stiffness was observed between peritoneal dialysis and hemodialysis groups.

Conclusions:

  • Arterial stiffness progresses with renal function decline in CKD.
  • Both peritoneal dialysis and hemodialysis are effective in improving arterial stiffness in uremic patients.
  • These findings highlight the potential of dialysis to mitigate cardiovascular complications in CKD.
Abstract

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