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A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
08:27

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

New lessons from random X-chromosome inactivation in the mouse

Philippe Clerc1, Philip Avner

  • 1Génétique Moléculaire Murine, Department of Developmental Biology, CNRS URA2578, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France.

Journal of Molecular Biology
|February 19, 2011
PubMed
Summary

X-chromosome inactivation (XCI) silences one X chromosome in female mammals. Recent discoveries highlight the roles of long noncoding RNAs, pluripotency factors, and chromosome structure in this key epigenetic process.

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X-inactivation01:58

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X-Inactivation01:58

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