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Updated: Jun 4, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Cimetidine: an anticancer drug?
Martina Kubecova1, Katarina Kolostova, Daniela Pinterova
1Department of Radiotherapy and Oncology, Charles University in Prague, Third Faculty of Medicine and Faculty Hospital Kralovske Vinohrady, Czech Republic.
Abstract:
Cimetidine, H(2) receptor antagonists, is commonly prescribed for gastric and duodenal ulcer disease. Additionally, cimetidine has been shown to have anticancer effects. This review describes the mechanism of antitumor action of cimetidine including its ability to interfere with tumor cell adhesion, angiogenesis and proliferation; its effect on the immune system; as well as inhibition of postoperative immunosuppression. Its anticancer effect is also compared to that of the other H(2) receptor antagonists as well as outcomes of cimetidine in clinical studies in cancer patients.
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