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Updated: Jun 4, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Cimetidine: an anticancer drug?
Martina Kubecova1, Katarina Kolostova, Daniela Pinterova
1Department of Radiotherapy and Oncology, Charles University in Prague, Third Faculty of Medicine and Faculty Hospital Kralovske Vinohrady, Czech Republic.
Cimetidine, an H(2) receptor antagonist, demonstrates anticancer effects by impacting tumor cell adhesion, angiogenesis, and proliferation. This review explores its antitumor mechanisms and clinical outcomes in cancer patients.
Area of Science:
- Oncology
- Pharmacology
- Immunology
Background:
- Cimetidine is a widely used H(2) receptor antagonist for gastrointestinal conditions.
- Emerging evidence suggests cimetidine possesses anticancer properties.
Purpose of the Study:
- To review the antitumor mechanisms of cimetidine.
- To compare cimetidine's anticancer effects with other H(2) receptor antagonists.
- To summarize clinical outcomes of cimetidine in cancer patients.
Main Methods:
- Literature review of studies on cimetidine's antitumor activity.
- Analysis of cimetidine's effects on tumor cell adhesion, angiogenesis, and proliferation.
- Evaluation of cimetidine's impact on the immune system and postoperative immunosuppression.
Main Results:
- Cimetidine interferes with tumor cell adhesion, angiogenesis, and proliferation.
- Cimetidine modulates the immune system and inhibits postoperative immunosuppression.
- Clinical studies show varied outcomes for cimetidine in cancer patients.
Conclusions:
- Cimetidine exhibits multifaceted antitumor actions.
- Further research is warranted to optimize cimetidine's use in cancer therapy.
- Cimetidine's role in oncology requires comprehensive evaluation.
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