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Nesidioblastosis associated with chronic experimental pancreatitis produced by a scorpion toxin, tityustoxin, in rats
G Novaes1, A Chetto-de-Queiroz, C De-Carvalho-Cardoso
1Departamento de Fisiologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brasil.
Abstract:
Tityustoxin (TsTx), the purified venom of the Brazilian scorpion Tityus serrulatus, was injected intravenously (50 micrograms/kg) into rats, producing a typical picture of chronic pancreatitis after 20 days. Nesidioblastosis, a lesion characterized by hyperplasia of the islets of Langerhans, was also detected in a high percentage (40%) of animals. TsTx-induced pancreatitis may be a useful model for the study of nesidioblastosis in laboratory animals.