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The Woven EndoBridge: a new aneurysm occlusion device
Y H Ding1, D A Lewis, R Kadirvel
1Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
AJNR. American Journal of Neuroradiology
|February 19, 2011
Summary
The WEB device shows promising immediate and long-term occlusion rates in experimental aneurysms. Histology confirms effective flow disruption and aneurysm healing.
Area of Science:
- Vascular Surgery
- Interventional Neuroradiology
- Biomaterials Engineering
Background:
- The WEB device is an intrasaccular braided-wire embolization device.
- It is designed for flow disruption at the aneurysm neck.
Purpose of the Study:
- Evaluate the acute and chronic performance of the WEB device.
- Assess immediacy, degree, and durability of aneurysm occlusion in an in vivo model.
Main Methods:
- WEB device implantation in 24 rabbit aneurysms.
- Follow-up at 1, 3, 6, and 12 months.
- Grading of flow disruption (DSA) and occlusion (3-point scale), followed by histologic analysis.
Main Results:
- Immediate complete/near-complete flow cessation in 83% of cases.
- Complete or near-complete occlusion achieved in 91% at follow-up.
- Histology revealed organized thrombus and connective tissue across the neck.
Conclusions:
- The WEB device demonstrated promising immediate and long-term aneurysm occlusion rates.
- Effective intra-aneurysmal flow disruption and healing were observed.
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