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Updated: Jun 4, 2026

A Laser-induced Mouse Model of Chronic Ocular Hypertension to Characterize Visual Defects
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Quantification of deficits in spatial visual function of mouse models for glaucoma.

Stephanie L Burroughs1, Simon Kaja, Peter Koulen

  • 1Vision Research Center and Department of Ophthalmology, University of Missouri-Kansas City, School of Medicine, Kansas City, Missouri 64108, USA.

Investigative Ophthalmology & Visual Science
|February 19, 2011
PubMed
Summary

DBA/2J and DBA/2NHsd mice develop age-related glaucoma with similar vision loss. DBA/2NHsd mice show poorer visual acuity earlier, making them a viable alternative model for pigmentary glaucoma research.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Neuroscience

Background:

  • DBA/2J mice are a common model for preclinical glaucoma studies.
  • They spontaneously develop chronic age-related pigmentary glaucoma.
  • The DBA/2NHsd substrain is less researched in this context.

Purpose of the Study:

  • To quantify visual impairment in DBA/2J and DBA/2NHsd mice before and after glaucoma onset.
  • To compare optokinetic reflex responses between these two mouse substrains.
  • To evaluate DBA/2NHsd mice as an alternative model for pigmentary glaucoma.

Main Methods:

  • Visual performance was assessed using a visuospatial testing box in male DBA/2NHsd and DBA/2J mice.
  • The optokinetic reflex was measured via manual detection of optomotor head tracking.

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  • Intraocular pressure (IOP) was determined using applanation tonometry.

    • Main Results:

    • Both DBA/2J and DBA/2NHsd mice exhibited age-related increases in IOP without significant differences between substrains.
    • Visual acuity and contrast sensitivity significantly decreased with age in both substrains.
    • DBA/2NHsd mice displayed poorer visual acuity at younger ages compared to age-matched DBA/2J mice.

    Conclusions:

    • Both DBA/2J and DBA/2NHsd mice present a progressive glaucomatous phenotype with age-related IOP increases and vision loss.
    • The similar progression of IOP and visual deficits supports their use as glaucoma models.
    • DBA/2NHsd mice are a suitable alternative model for studying pigmentary glaucoma.